8J6P: Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex

PDB ID: 8J6PDownload
MMDB ID: 239377
PDB Deposition Date: 2023/4/26
Updated in MMDB: 2023/12
Experimental Method:
electron microscopy
Resolution: 2.55  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8J6P: pentameric; determined by author
Molecular Components in 8J6P
Label Count Molecule
Proteins (5 molecules)
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Single FAB Chain (Scfv16)
Molecule annotation
1
Hydroxycarboxylic Acid Receptor 2
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
2
2
CHOLESTEROLCHOLESTEROL
3
1
NICOTINIC ACIDNICOTINIC ACID
4
1
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303