8J6I: Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892

PDB ID: 8J6IDownload
MMDB ID: 244835
PDB Deposition Date: 2023/4/26
Updated in MMDB: 2025/07
Experimental Method:
electron microscopy
Resolution: 2.92  Å
Source Organism:
Similar Structures:
Biological Unit for 8J6I: pentameric; determined by author
Molecular Components in 8J6I
Label Count Molecule
Proteins (5 molecules)
1
Hydroxycarboxylic Acid Receptor 2
(Gene symbol: HCAR2)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1
(Gene symbol: GNAI1)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
(Gene symbol: GNB1)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
(Gene symbol: GNG2)
Molecule annotation
1
Scfv16
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303