8ITZ: Crystal structure of human Galectin-3 in complex with small molecule inhibitor

PDB ID: 8ITZDownload
MMDB ID: 244522
PDB Deposition Date: 2023/3/23
Updated in MMDB: 2024/04
Experimental Method:
x-ray diffraction
Resolution: 1.22  Å
Source Organism:
Similar Structures:
Biological Unit for 8ITZ: monomeric; determined by author and by software (PISA)
Molecular Components in 8ITZ
Label Count Molecule
Protein (1 molecule)
1
Galectin-3
(Gene symbol: LGALS3)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
CHLORIDE IONCHLORIDE ION
2
1
2-[(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-5-oxidanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-yl]oxyethanoic acid2-[(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-5-oxidanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-yl]oxyethanoic acid
3
1
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303