8IOW: Cryo-EM structure of the sarilumab Fab/IL-6R complex

PDB ID: 8IOWDownload
MMDB ID: 244252
PDB Deposition Date: 2023/3/13
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.2  Å
Source Organism:
Similar Structures:
Biological Unit for 8IOW: tetrameric; determined by author
Molecular Components in 8IOW
Label Count Molecule
Proteins (4 molecules)
2
Interleukin-6 Receptor Subunit Alpha
(Gene symbol: IL6R)
Molecule annotation
1
Light Chain of Sarilumab FAB
Molecule annotation
1
Heavy Chain of Sarilumab FAB
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303