8IO3: Cryo-EM structure of human HCN3 channel with cilobradine

PDB ID: 8IO3Download
MMDB ID: 245107
PDB Deposition Date: 2023/3/10
Updated in MMDB: 2025/06
Experimental Method:
electron microscopy
Resolution: 3.02  Å
Source Organism:
Similar Structures:
Biological Unit for 8IO3: tetrameric; determined by author
Molecular Components in 8IO3
Label Count Molecule
Proteins (4 molecules)
4
Potassium/sodium Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3
(Gene symbol: HCN3)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
3-[[(3~{S})-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1~{H}-3-benzazepin-4-one3-[[(3~{S})-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1~{H}-3-benzazepin-4-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303