8IG0: Crystal structure of menin in complex with DS-1594b

PDB ID: 8IG0Download
MMDB ID: 228200
PDB Deposition Date: 2023/2/20
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8IG0: dimeric; determined by author and by software (PISA)
Molecular Components in 8IG0
Label Count Molecule
Proteins (2 molecules)
2
Menin
(Gene symbol: MEN1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
(1R,2S,4R)-4-[[4-(5,6-dimethoxypyridazin-3-yl)phenyl]methylamino]-2-[methyl-[6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]cyclopentan-1-ol(1R,2S,4R)-4-[[4-(5,6-dimethoxypyridazin-3-yl)phenyl]methylamino]-2-[methyl-[6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]cyclopentan-1-ol
2
2
Molecule information is not available.
3
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303