8I2M: The crystal structure of homodimeric E. coli tryptophanyl-tRNA synthetase bound with niraparib at one of its two active sites

PDB ID: 8I2MDownload
MMDB ID: 229042
PDB Deposition Date: 2023/1/14
Updated in MMDB: 2024/06
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8I2M: dimeric; determined by author and by software (PISA)
Molecular Components in 8I2M
Label Count Molecule
Proteins (2 molecules)
2
Tryptophan--trna Ligase
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
2
3
SULFATE IONSULFATE ION
3
1
TRYPTOPHANYL-5'AMPTRYPTOPHANYL-5'AMP
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303