8I2G: FSHR-Follicle stimulating hormone-compound 716340-Gs complex

PDB ID: 8I2GDownload
MMDB ID: 228519
PDB Deposition Date: 2023/1/14
Updated in MMDB: 2023/04
Experimental Method:
electron microscopy
Resolution: 2.8  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8I2G: heptameric; determined by author
Molecular Components in 8I2G
Label Count Molecule
Proteins (7 molecules)
1
Chimera of Guanine Nucleotide-binding Protein G(s) Subunit Alpha and Guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Xlas
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Nb35
Molecule annotation
1
Follicle-stimulating Hormone Receptor
Molecule annotation
1
Glycoprotein Hormones Alpha Chain
Molecule annotation
1
Follitropin Subunit Beta
Molecule annotation
Chemicals and Non-standard biopolymers (25 molecules)
1
6
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
13
CHOLESTEROLCHOLESTEROL
3
3
PALMITIC ACIDPALMITIC ACID
4
2
MYRISTIC ACIDMYRISTIC ACID
5
1
N-tert-butyl-N-ethyl-8-methoxy-9-propan-2-yloxy-1-thiophen-2-yl-5,6-dihydroimidazo[5,1-a]isoquinoline-3-carboxamideN-tert-butyl-N-ethyl-8-methoxy-9-propan-2-yloxy-1-thiophen-2-yl-5,6-dihydroimidazo[5,1-a]isoquinoline-3-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303