8I2B: Human SIRT6 in complex with inhibitor 7702

PDB ID: 8I2BDownload
MMDB ID: 241332
PDB Deposition Date: 2023/1/14
Updated in MMDB: 2025/08
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 8I2B: hexameric; determined by author and by software (PISA)
Molecular Components in 8I2B
Label Count Molecule
Proteins (6 molecules)
6
Nad-dependent Protein Deacylase Sirtuin-6
(Gene symbol: SIRT6)
Molecule annotation
Chemicals and Non-standard biopolymers (42 molecules)
1
9
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
2
6
N1-[[4-(4-aminophenyl)sulfanyl-3-(trifluoromethyl)phenyl]methoxy]benzene-1,4-dicarboxamideN1-[[4-(4-aminophenyl)sulfanyl-3-(trifluoromethyl)phenyl]methoxy]benzene-1,4-dicarboxamide
3
6
[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
4
6
ZINC IONZINC ION
5
15
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303