8HMA: Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with tetrandrine (TET)

PDB ID: 8HMADownload
MMDB ID: 245733
PDB Deposition Date: 2022/12/2
Updated in MMDB: 2025/06
Experimental Method:
electron microscopy
Resolution: 3.4  Å
Source Organism:
Similar Structures:
Biological Unit for 8HMA: trimeric; determined by author
Molecular Components in 8HMA
Label Count Molecule
Proteins (3 molecules)
1
Voltage-dependent L-type Calcium Channel Subunit Alpha
Molecule annotation
1
Isoform 2C of Voltage-dependent L-type Calcium Channel Subunit Beta-2
Molecule annotation
1
Voltage-dependent Calcium Channel Subunit Alpha-2/delta-1
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
1
HEXADECANEHEXADECANE
2
3
1,2-Distearoyl-sn-glycerophosphoethanolamine1,2-Distearoyl-sn-glycerophosphoethanolamine
3
1
1,2-Distearoyl-sn-glycerophosphoethanolamine1,2-Distearoyl-sn-glycerophosphoethanolamine
4
2
CALCIUM IONCALCIUM ION
5
11
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
6
1
beta-D-mannopyranosebeta-D-mannopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303