8HKS: Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Pamiparib(BGB-290)

PDB ID: 8HKSDownload
MMDB ID: 246027
PDB Deposition Date: 2022/11/28
Updated in MMDB: 2025/05
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 8HKS: monomeric; determined by author
Molecular Components in 8HKS
Label Count Molecule
Protein (1 molecule)
1
Poly [adp-ribose] Polymerase 2
(Gene symbol: PARP2)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
GLYCEROLGLYCEROL
2
1
(2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one(2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303