8HK1: The cryo-EM structure of human pre-17S U2 snRNP

PDB ID: 8HK1Download
MMDB ID: 227709
PDB Deposition Date: 2022/11/24
Updated in MMDB: 2023/08
Experimental Method:
electron microscopy
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 8HK1: 21-meric; determined by author
Molecular Components in 8HK1
Label Count Molecule
Proteins (20 molecules)
1
Splicing Factor 3B Subunit 1
(Gene symbol: SF3B1)
Molecule annotation
1
Splicing Factor 3B Subunit 2
(Gene symbol: SF3B2)
Molecule annotation
1
Splicing Factor 3B Subunit 3
(Gene symbol: SF3B3)
Molecule annotation
1
Splicing Factor 3B Subunit 4
(Gene symbol: SF3B4)
Molecule annotation
1
Splicing Factor 3B Subunit 5
(Gene symbol: SF3B5)
Molecule annotation
1
PHD Finger-like Domain-containing Protein 5A
(Gene symbol: PHF5A)
Molecule annotation
1
Splicing Factor 3A Subunit 1
(Gene symbol: SF3A1)
Molecule annotation
1
Splicing Factor 3A Subunit 2
(Gene symbol: SF3A2)
Molecule annotation
1
Splicing Factor 3A Subunit 3
(Gene symbol: SF3A3)
Molecule annotation
1
HIV Tat-specific Factor 1
(Gene symbol: HTATSF1)
Molecule annotation
1
Atp-dependent RNA Helicase Ddx42
(Gene symbol: DDX42)
Molecule annotation
1
U2 Small Nuclear Ribonucleoprotein A'
(Gene symbol: SNRPA1)
Molecule annotation
1
U2 Small Nuclear Ribonucleoprotein B''
(Gene symbol: SNRPB2)
Molecule annotation
1
Small Nuclear Ribonucleoprotein SM D2
(Gene symbol: SNRPD2)
Molecule annotation
1
Small Nuclear Ribonucleoprotein F
(Gene symbol: SNRPF)
Molecule annotation
1
Small Nuclear Ribonucleoprotein E
(Gene symbol: SNRPE)
Molecule annotation
1
Small Nuclear Ribonucleoprotein G
(Gene symbol: SNRPG)
Molecule annotation
1
Small Nuclear Ribonucleoprotein SM D3
(Gene symbol: SNRPD3)
Molecule annotation
1
Small Nuclear Ribonucleoprotein-associated Proteins B and B'
(Gene symbol: SNRPB)
Molecule annotation
1
Small Nuclear Ribonucleoprotein SM D1
(Gene symbol: SNRPD1)
Molecule annotation
Nucleotide(1 molecule)
1
U2 Snrna
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
[(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R},3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylate[(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R},3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylate
2
4
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303