8HFI: Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant desipramine in an inward-open state at resolution of 2.5 angstrom

PDB ID: 8HFIDownload
MMDB ID: 246897
PDB Deposition Date: 2022/11/10
Updated in MMDB: 2024/09
Experimental Method:
electron microscopy
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 8HFI: monomeric; determined by author
Molecular Components in 8HFI
Label Count Molecule
Protein (1 molecule)
1
Sodium-dependent Noradrenaline Transporter
(Gene symbol: SLC6A2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE
2
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303