8H6L: Cryo-EM structure of human exon-defined spliceosome in the early B state

PDB ID: 8H6LDownload
MMDB ID: 246020
PDB Deposition Date: 2022/10/18
Updated in MMDB: 2025/08
Experimental Method:
electron microscopy
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8H6L: 59-meric; determined by author
Molecular Components in 8H6L
Label Count Molecule
Proteins (54 molecules)
1
Pre-mrna-processing-splicing Factor 8
Molecule annotation
1
116 KDA U5 Small Nuclear Ribonucleoprotein Component
Molecule annotation
1
U5 Small Nuclear Ribonucleoprotein 200 KDA Helicase
Molecule annotation
1
U5 Small Nuclear Ribonucleoprotein 40 KDA Protein
Molecule annotation
3
Isoform Sm-b of Small Nuclear Ribonucleoprotein-associated Proteins B and B'
Molecule annotation
3
Small Nuclear Ribonucleoprotein SM D1
Molecule annotation
3
Small Nuclear Ribonucleoprotein SM D2
Molecule annotation
3
Small Nuclear Ribonucleoprotein F
Molecule annotation
3
Small Nuclear Ribonucleoprotein E
Molecule annotation
3
Small Nuclear Ribonucleoprotein G
Molecule annotation
3
Small Nuclear Ribonucleoprotein SM D3
Molecule annotation
1
U6 Snrna-associated Sm-like Protein Lsm2
Molecule annotation
1
U6 Snrna-associated Sm-like Protein Lsm3
Molecule annotation
1
U6 Snrna-associated Sm-like Protein Lsm4
Molecule annotation
1
U6 Snrna-associated Sm-like Protein Lsm5
Molecule annotation
1
U6 Snrna-associated Sm-like Protein Lsm6
Molecule annotation
1
U6 Snrna-associated Sm-like Protein Lsm7
Molecule annotation
1
U6 Snrna-associated Sm-like Protein Lsm8
Molecule annotation
1
U4/u6 Small Nuclear Ribonucleoprotein Prp3
Molecule annotation
1
U4/u6 Small Nuclear Ribonucleoprotein Prp4
Molecule annotation
1
U4/u6 Small Nuclear Ribonucleoprotein Prp31
Molecule annotation
1
Nhp2-like Protein 1
Molecule annotation
1
Thioredoxin-like Protein 4A
Molecule annotation
1
Pre-mrna-processing Factor 6
Molecule annotation
1
Peptidyl-prolyl Cis-trans Isomerase H
Molecule annotation
1
WW Domain-binding Protein 4
Molecule annotation
1
U4/u6.u5 Tri-snrnp-associated Protein 1
Molecule annotation
1
Wd40 Repeat-containing Protein Smu1
Molecule annotation
1
U2 Small Nuclear Ribonucleoprotein A'
Molecule annotation
1
U2 Small Nuclear Ribonucleoprotein B''
Molecule annotation
1
Splicing Factor 3A Subunit 1
Molecule annotation
1
Splicing Factor 3A Subunit 2
Molecule annotation
1
Splicing Factor 3A Subunit 3
Molecule annotation
1
Splicing Factor 3B Subunit 1
Molecule annotation
1
Splicing Factor 3B Subunit 2
Molecule annotation
1
Splicing Factor 3B Subunit 3
Molecule annotation
1
Splicing Factor 3B Subunit 4
Molecule annotation
1
Splicing Factor 3B Subunit 6
Molecule annotation
1
PHD Finger-like Domain-containing Protein 5A
Molecule annotation
1
Splicing Factor 3B Subunit 5
Molecule annotation
Nucleotides(5 molecules)
1
Pre-mrna
Molecule annotation
1
U5 Snrna
Molecule annotation
1
U6 Snrna
Molecule annotation
1
U4 Snrna
Molecule annotation
1
U2 Snrna
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
1
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB