8H4R: The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus

PDB ID: 8H4RDownload
MMDB ID: 236619
PDB Deposition Date: 2022/10/11
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.75  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8H4R: dimeric; determined by author and by software (PISA)
Molecular Components in 8H4R
Label Count Molecule
Proteins (2 molecules)
1
Glutathione S-transferase Class-mu 26 KDA Isozyme,cyclin-dependent Kinase 3
Molecule annotation
1
G1/s-specific Cyclin-e1
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
1
3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium
2
6
SULFATE IONSULFATE ION
3
2
GLYCEROLGLYCEROL
4
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303