8GZ2: Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin

PDB ID: 8GZ2Download
MMDB ID: 227705
PDB Deposition Date: 2022/9/24
Updated in MMDB: 2025/05
Experimental Method:
electron microscopy
Resolution: 3.3  Å
Source Organism:
Similar Structures:
Biological Unit for 8GZ2: trimeric; determined by author
Molecular Components in 8GZ2
Label Count Molecule
Proteins (3 molecules)
1
Sodium Channel Subunit Beta-1
(Gene symbol: SCN1B)
Molecule annotation
1
Sodium Channel Protein Type 8 Subunit Alpha
(Gene symbol: SCN8A)
Molecule annotation
1
Sodium Channel Subunit Beta-2
(Gene symbol: SCN2B)
Molecule annotation
Chemicals and Non-standard biopolymers (18 molecules)
1
12
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
5
beta-D-mannopyranosebeta-D-mannopyranose
3
1
(1R,2S,3S,4R,5R,9S,11S,12S,14R)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name)(1R,2S,3S,4R,5R,9S,11S,12S,14R)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name)
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303