8GNE: Crystal structure of human adenosine A2A receptor in complex with an insurmountable inverse agonist, KW-6356

PDB ID: 8GNEDownload
MMDB ID: 228160
PDB Deposition Date: 2022/8/23
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 8GNE: monomeric; determined by author
Molecular Components in 8GNE
Label Count Molecule
Protein (1 molecule)
1
Adenosine Receptor A2a,soluble Cytochrome B562
(Gene symbol: ADORA2A)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
1
~{N}-[4-(furan-2-yl)-5-(oxan-4-ylcarbonyl)-1,3-thiazol-2-yl]-6-methyl-pyridine-3-carboxamide~{N}-[4-(furan-2-yl)-5-(oxan-4-ylcarbonyl)-1,3-thiazol-2-yl]-6-methyl-pyridine-3-carboxamide
2
3
CHOLESTEROLCHOLESTEROL
3
18
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
4
1
2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL
5
1
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303