8GM5: Functional construct of the Eukaryotic elongation factor 2 kinase bound to Calmodulin, ADP and to the A-484954 inhibitor and showing two conformations for the 498-520 loop

PDB ID: 8GM5Download
MMDB ID: 230919
PDB Deposition Date: 2023/3/24
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.12  Å
Source Organism:
Similar Structures:
Biological Unit for 8GM5: dimeric; determined by author and by software (PISA)
Molecular Components in 8GM5
Label Count Molecule
Proteins (2 molecules)
1
Eukaryotic Elongation Factor 2 Kinase
(Gene symbol: EEF2K)
Molecule annotation
1
Calmodulin-1
(Gene symbol: CALM1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
2
1
7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide
3
1
ZINC IONZINC ION
4
2
CALCIUM IONCALCIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303