8GKZ: Human mitochondrial serine hydroxymethyltransferase (SHMT2) Y105F in complex with PLP, glycine and AGF362 inhibitor

PDB ID: 8GKZDownload
MMDB ID: 244242
PDB Deposition Date: 2023/3/20
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 2.75  Å
Source Organism:
Similar Structures:
Biological Unit for 8GKZ: tetrameric; determined by author and by software (PISA)
Molecular Components in 8GKZ
Label Count Molecule
Proteins (4 molecules)
4
Serine Hydroxymethyltransferase, Mitochondrial
(Gene symbol: SHMT2)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
4
GLYCINEGLYCINE
2
4
PYRIDOXAL-5'-PHOSPHATEPYRIDOXAL-5'-PHOSPHATE
3
2
N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acidN-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303