8GKU: Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF355 inhibitor

PDB ID: 8GKUDownload
MMDB ID: 244239
PDB Deposition Date: 2023/3/20
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 3.06  Å
Source Organism:
Similar Structures:
Biological Unit for 8GKU: tetrameric; determined by author and by software (PISA)
Molecular Components in 8GKU
Label Count Molecule
Proteins (4 molecules)
4
Serine Hydroxymethyltransferase, Mitochondrial
(Gene symbol: SHMT2)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
2
N-{4-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]-2-fluorobenzoyl}-D-glutamic acidN-{4-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]-2-fluorobenzoyl}-D-glutamic acid
2
2
GLYCINEGLYCINE
3
4
PYRIDOXAL-5'-PHOSPHATEPYRIDOXAL-5'-PHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303