8GHE: The structure of h12-LOX in tetrameric form bound to endogenous inhibitor oleoyl-CoA

PDB ID: 8GHEDownload
MMDB ID: 233886
PDB Deposition Date: 2023/3/9
Updated in MMDB: 2023/10
Experimental Method:
electron microscopy
Resolution: 2.05  Å
Source Organism:
Similar Structures:
Biological Unit for 8GHE: tetrameric; determined by author
Molecular Components in 8GHE
Label Count Molecule
Proteins (4 molecules)
4
Polyunsaturated Fatty Acid Lipoxygenase Alox12
(Gene symbol: ALOX12)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
4
FE (II) IONFE (II) ION
2
1
S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303