8GHD: The structure of h12-LOX in hexameric form bound to inhibitor ML355 and arachidonic acid

PDB ID: 8GHDDownload
MMDB ID: 233885
PDB Deposition Date: 2023/3/9
Updated in MMDB: 2023/10
Experimental Method:
electron microscopy
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 8GHD: hexameric; determined by author
Molecular Components in 8GHD
Label Count Molecule
Proteins (6 molecules)
6
Polyunsaturated Fatty Acid Lipoxygenase Alox12
(Gene symbol: ALOX12)
Molecule annotation
Chemicals and Non-standard biopolymers (18 molecules)
1
6
FE (II) IONFE (II) ION
2
6
N-(1,3-benzothiazol-2-yl)-4-{[(2-hydroxy-3-methoxyphenyl)methyl]amino}benzene-1-sulfonamideN-(1,3-benzothiazol-2-yl)-4-{[(2-hydroxy-3-methoxyphenyl)methyl]amino}benzene-1-sulfonamide
3
6
ARACHIDONIC ACIDARACHIDONIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303