8GCY: Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor

PDB ID: 8GCYDownload
MMDB ID: 228159
PDB Deposition Date: 2023/3/3
Updated in MMDB: 2024/04
Experimental Method:
x-ray diffraction
Resolution: 1.81  Å
Source Organism:
Similar Structures:
Biological Unit for 8GCY: monomeric; determined by author
Molecular Components in 8GCY
Label Count Molecule
Protein (1 molecule)
1
E3 Ubiquitin-protein Ligase Cbl-b
(Gene symbol: CBLB)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
ZINC IONZINC ION
2
1
2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one
3
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
SULFATE IONSULFATE ION
5
1
Molecule information is not available.
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303