8G8O: The crystal structure of JAK2 in complex with Compound 31

PDB ID: 8G8ODownload
MMDB ID: 231928
PDB Deposition Date: 2023/2/18
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 8G8O: dimeric; determined by author
Molecular Components in 8G8O
Label Count Molecule
Proteins (2 molecules)
2
Tyrosine-protein Kinase Jak2
(Gene symbol: JAK2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
[1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile[1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile
2
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303