8G4O: Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with didesethylflurazepam and endogenous GABA

PDB ID: 8G4ODownload
MMDB ID: 235798
PDB Deposition Date: 2023/2/10
Updated in MMDB: 2023/11
Experimental Method:
electron microscopy
Resolution: 3.06  Å
Source Organism:
Similar Structures:
Biological Unit for 8G4O: nonameric; determined by author
Molecular Components in 8G4O
Label Count Molecule
Proteins (9 molecules)
2
Gamma-aminobutyric Acid Receptor Subunit Alpha-1
(Gene symbol: Gabra1)
Molecule annotation
2
Gamma-aminobutyric Acid Receptor Subunit Beta-2
(Gene symbol: Gabrb2)
Molecule annotation
1
Gamma-aminobutyric Acid Receptor Subunit Gamma-2
(Gene symbol: Gabrg2)
Molecule annotation
2
Heavy Chain of 8E3 FAB
Molecule annotation
2
Light Chain of 8E3 FAB
Molecule annotation
Chemicals and Non-standard biopolymers (39 molecules)
1
15
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
7
beta-D-mannopyranosebeta-D-mannopyranose
3
14
alpha-D-mannopyranosealpha-D-mannopyranose
4
2
GAMMA-AMINO-BUTANOIC ACIDGAMMA-AMINO-BUTANOIC ACID
5
1
(5M)-1-(2-aminoethyl)-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one(5M)-1-(2-aminoethyl)-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303