8G1Q: Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB

PDB ID: 8G1QDownload
MMDB ID: 233296
PDB Deposition Date: 2023/2/2
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 3.73  Å
Source Organism:
Similar Structures:
Biological Unit for 8G1Q: tetrameric; determined by author
Molecular Components in 8G1Q
Label Count Molecule
Proteins (4 molecules)
1
Transcription Activator Brg1
(Gene symbol: SMARCA4)
Molecule annotation
1
Elongin-b
(Gene symbol: ELOB)
Molecule annotation
1
Elongin-c
(Gene symbol: ELOC)
Molecule annotation
1
VON Hippel-lindau Disease Tumor Suppressor
(Gene symbol: VHL)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
SODIUM IONSODIUM ION
2
1
N-(2-{4-[(6M)-3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl}pyridine-4-carbonyl)-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamideN-(2-{4-[(6M)-3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl}pyridine-4-carbonyl)-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide
3
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303