8FYZ: Crystal structure of human PARP1 ART domain bound to inhibitor UKTT10 (compound 13)

PDB ID: 8FYZDownload
MMDB ID: 242248
PDB Deposition Date: 2023/1/27
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 3.4  Å
Source Organism:
Similar Structures:
Biological Unit for 8FYZ: monomeric; determined by author
Molecular Components in 8FYZ
Label Count Molecule
Protein (1 molecule)
1
Poly [adp-ribose] Polymerase 1, Processed C-terminus
(Gene symbol: PARP1)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
2
1
CITRIC ACIDCITRIC ACID
3
1
(2P)-2-{3-[(4R)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carbonyl]phenyl}-1H-benzimidazole-4-carboxamide(2P)-2-{3-[(4R)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carbonyl]phenyl}-1H-benzimidazole-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303