8FWW: Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and noncompetitive inhibitor perampanel

PDB ID: 8FWWDownload
MMDB ID: 229264
PDB Deposition Date: 2023/1/23
Updated in MMDB: 2023/04
Experimental Method:
electron microscopy
Resolution: 3.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8FWW: tetrameric; determined by author
Molecular Components in 8FWW
Label Count Molecule
Proteins (4 molecules)
4
Glutamate Receptor Ionotropic, Kainate 2
(Gene symbol: Grik2)
Molecule annotation
Chemicals and Non-standard biopolymers (49 molecules)
1
14
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
4
beta-D-mannopyranosebeta-D-mannopyranose
3
4
4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
4
16
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
5
2
2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile
6
7
SODIUM IONSODIUM ION
7
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303