8FOW: Ternary complex of CDK2 with small molecule ligands TW8672 and Dinaciclib

PDB ID: 8FOWDownload
MMDB ID: 230894
PDB Deposition Date: 2023/1/3
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8FOW: monomeric; determined by author
Molecular Components in 8FOW
Label Count Molecule
Protein (1 molecule)
1
Cyclin-dependent Kinase 2
(Gene symbol: CDK2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
1
3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium
3
1
2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303