8FO7: Cryo-EM structure of LRRK2 bound to type I inhibitor LRRK2-IN-1

PDB ID: 8FO7Download
MMDB ID: 241254
PDB Deposition Date: 2022/12/29
Updated in MMDB: 2025/05
Experimental Method:
electron microscopy
Resolution: 3.52  Å
Source Organism:
Similar Structures:
Biological Unit for 8FO7: monomeric; determined by author
Molecular Components in 8FO7
Label Count Molecule
Protein (1 molecule)
1
Leucine-rich Repeat Serine/threonine-protein Kinase 2
(Gene symbol: LRRK2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
2
1
2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303