8FNP: Structure of E138K/G140S/Q148H HIV-1 intasome with Dolutegravir bound

PDB ID: 8FNPDownload
MMDB ID: 233867
PDB Deposition Date: 2022/12/28
Updated in MMDB: 2023/08
Experimental Method:
electron microscopy
Resolution: 2.2  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8FNP: dodecameric; determined by author
Molecular Components in 8FNP
Label Count Molecule
Proteins (8 molecules)
8
Lamina-associated Polypeptide 2, Isoform Alpha,integrase Chimera
Molecule annotation
Nucleotides(4 molecules)
2
DNA (27-mer)
Molecule annotation
2
DNA (25-mer)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
4
MAGNESIUM IONMAGNESIUM ION
2
2
ZINC IONZINC ION
3
2
(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303