8FN0: CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator

PDB ID: 8FN0Download
MMDB ID: 228497
PDB Deposition Date: 2022/12/26
Updated in MMDB: 2023/04
Experimental Method:
electron microscopy
Resolution: 2.89  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 8FN0: hexameric; determined by author
Molecular Components in 8FN0
Label Count Molecule
Proteins (6 molecules)
1
Neurotensin Receptor Type 1
Molecule annotation
1
Neurotensin/neuromedin N
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Minigo
Molecule annotation
1
Scfv16
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303