8FLM: Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53

PDB ID: 8FLMDownload
MMDB ID: 237444
PDB Deposition Date: 2022/12/21
Updated in MMDB: 2023/11
Experimental Method:
electron microscopy
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 8FLM: tetrameric; determined by author
Molecular Components in 8FLM
Label Count Molecule
Proteins (4 molecules)
4
Stimulator of Interferon Genes Protein
(Gene symbol: STING1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid
2
2
cGAMPcGAMP
3
2
1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303