8FLK: Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2

PDB ID: 8FLKDownload
MMDB ID: 237443
PDB Deposition Date: 2022/12/21
Updated in MMDB: 2023/11
Experimental Method:
electron microscopy
Resolution: 4  Å
Source Organism:
Similar Structures:
Biological Unit for 8FLK: tetrameric; determined by author
Molecular Components in 8FLK
Label Count Molecule
Proteins (4 molecules)
4
Stimulator of Interferon Genes Protein
(Gene symbol: STING1)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
cGAMPcGAMP
2
2
4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303