8FJT: Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF362 inhibitor

PDB ID: 8FJTDownload
MMDB ID: 242526
PDB Deposition Date: 2022/12/20
Updated in MMDB: 2024/02
Experimental Method:
x-ray diffraction
Resolution: 2.47  Å
Source Organism:
Similar Structures:
Biological Unit for 8FJT: dimeric; determined by software (PISA)
Molecular Components in 8FJT
Label Count Molecule
Proteins (2 molecules)
2
Serine Hydroxymethyltransferase, Mitochondrial
(Gene symbol: SHMT2)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]
2
2
N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acidN-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid
3
1
GLYCINEGLYCINE
4
1
PYRIDOXAL-5'-PHOSPHATEPYRIDOXAL-5'-PHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303