8FHS: Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution

PDB ID: 8FHSDownload
MMDB ID: 239695
PDB Deposition Date: 2022/12/15
Updated in MMDB: 2024/12
Experimental Method:
electron microscopy
Resolution: 3.3  Å
Source Organism:
Similar Structures:
Biological Unit for 8FHS: trimeric; determined by author
Molecular Components in 8FHS
Label Count Molecule
Proteins (3 molecules)
1
Voltage-dependent L-type Calcium Channel Subunit Alpha-1c
(Gene symbol: CACNA1C)
Molecule annotation
1
Voltage-dependent Calcium Channel Subunit Alpha-2/delta-1
(Gene symbol: CACNA2D1)
Molecule annotation
1
Voltage-dependent L-type Calcium Channel Subunit Beta-3
(Gene symbol: CACNB3)
Molecule annotation
Chemicals and Non-standard biopolymers (25 molecules)
1
15
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
CALCIUM IONCALCIUM ION
3
1
(2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone(2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone
4
1
SofosbuvirSofosbuvir
5
2
1,2-Distearoyl-sn-glycerophosphoethanolamine1,2-Distearoyl-sn-glycerophosphoethanolamine
6
4
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303