8FH8: Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-003 Soaked In Hydrogen Peroxide

PDB ID: 8FH8Download
MMDB ID: 240134
PDB Deposition Date: 2022/12/13
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8FH8: monomeric; determined by author
Molecular Components in 8FH8
Label Count Molecule
Protein (1 molecule)
1
Aldo-keto Reductase Family 1 Member B1
(Gene symbol: AKR1B1)
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
1
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
1
{7-[(5-chloro-1,3-benzothiazol-2-yl)methyl]-8-oxo-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl}acetic acid{7-[(5-chloro-1,3-benzothiazol-2-yl)methyl]-8-oxo-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl}acetic acid
3
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
13
HYDROGEN PEROXIDEHYDROGEN PEROXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303