8FGS: Structure of human endothelial nitric oxide synthase heme domain in complex with 6-(5-(2-(diethylamino)ethyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine

PDB ID: 8FGSDownload
MMDB ID: 236581
PDB Deposition Date: 2022/12/12
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.8449  Å
Source Organism:
Similar Structures:
Biological Unit for 8FGS: dimeric; determined by author and by software (PISA)
Molecular Components in 8FGS
Label Count Molecule
Proteins (2 molecules)
2
Nitric Oxide Synthase, Endothelial
(Gene symbol: NOS3)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
2
PROTOPORPHYRIN IX CONTAINING FEPROTOPORPHYRIN IX CONTAINING FE
2
2
5,6,7,8-TETRAHYDROBIOPTERIN5,6,7,8-TETRAHYDROBIOPTERIN
3
2
6-(2-{5-[2-(diethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methylpyridin-2-amine6-(2-{5-[2-(diethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methylpyridin-2-amine
4
7
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
5
7
GLYCEROLGLYCEROL
6
2
CHLORIDE IONCHLORIDE ION
7
1
ZINC IONZINC ION
8
1
GADOLINIUM ATOMGADOLINIUM ATOM
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303