8FGM: Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-(difluoromethyl)-6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)pyridin-2-amine

PDB ID: 8FGMDownload
MMDB ID: 236575
PDB Deposition Date: 2022/12/12
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8FGM: dimeric; determined by author and by software (PISA)
Molecular Components in 8FGM
Label Count Molecule
Proteins (2 molecules)
2
Nitric Oxide Synthase, Brain
(Gene symbol: NOS1)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
PROTOPORPHYRIN IX CONTAINING FE (Link to PubChem not yet available)PROTOPORPHYRIN IX CONTAINING FE
2
2
5,6,7,8-TETRAHYDROBIOPTERIN (Link to PubChem not yet available)5,6,7,8-TETRAHYDROBIOPTERIN
3
2
4-(difluoromethyl)-6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)pyridin-2-amine (Link to PubChem not yet available)4-(difluoromethyl)-6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)pyridin-2-amine
4
3
GLYCEROL (Link to PubChem not yet available)GLYCEROL
5
1
ZINC ION (Link to PubChem not yet available)ZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303