8FFE: Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide

PDB ID: 8FFEDownload
MMDB ID: 227682
PDB Deposition Date: 2022/12/8
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 1.72  Å
Source Organism:
Similar Structures:
Biological Unit for 8FFE: trimeric; determined by author and by software (PISA)
Molecular Components in 8FFE
Label Count Molecule
Proteins (3 molecules)
1
Low-density Lipoprotein Receptor-related Protein 6
(Gene symbol: LRP6)
Molecule annotation
1
Yw210.09 FAB Heavy Chain With Engineered Xwnt8 NC Peptide and Linker
Molecule annotation
1
Yw210.09 FAB Light Chain
Molecule annotation
Chemicals and Non-standard biopolymers (23 molecules)
1
6
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
4
alpha-L-fucopyranosealpha-L-fucopyranose
3
1
beta-D-mannopyranosebeta-D-mannopyranose
4
1
alpha-D-mannopyranosealpha-D-mannopyranose
5
7
GLYCEROLGLYCEROL
6
3
SODIUM IONSODIUM ION
7
1
SUCCINIC ACIDSUCCINIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303