8FF0: Structure of BTK kinase domain with the second-generation inhibitor tirabrutinib

PDB ID: 8FF0Download
MMDB ID: 232475
PDB Deposition Date: 2022/12/7
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8FF0: monomeric; determined by author and by software (PISA)
Molecular Components in 8FF0
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase BTK
(Gene symbol: Btk)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
6-azanyl-9-[(3~{R})-1-[(~{E})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one6-azanyl-9-[(3~{R})-1-[(~{E})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303