8FE9: Crystal structure of Ack1 kinase K161Q mutant in complex with the selective inhibitor (R)-9b

PDB ID: 8FE9Download
MMDB ID: 255507
PDB Deposition Date: 2022/12/6
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 3.2  Å
Source Organism:
Similar Structures:
Biological Unit for 8FE9: monomeric; determined by author
Molecular Components in 8FE9
Label Count Molecule
Protein (1 molecule)
1
Activated Cdc42 Kinase 1
(Gene symbol: TNK2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N~4~-{[(2R)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N~4~-{[(2R)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303