8FD7: Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin

PDB ID: 8FD7Download
MMDB ID: 228144
PDB Deposition Date: 2022/12/2
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.1  Å
Source Organism:
Oryctolagus cuniculus▼
Similar Structures:
Biological Unit for 8FD7: trimeric; determined by author
Molecular Components in 8FD7
Label Count Molecule
Proteins (3 molecules)
1
Voltage-dependent Calcium Channel Subunit Alpha-2/delta-1
Molecule annotation
1
Voltage-dependent L-type Calcium Channel Subunit Alpha-1c
Molecule annotation
1
Voltage-dependent L-type Calcium Channel Subunit Beta-3
Molecule annotation
Chemicals and Non-standard biopolymers (20 molecules)
1
10
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
[1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID[1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID
3
3
CALCIUM IONCALCIUM ION
4
1
SODIUM IONSODIUM ION
5
1
(2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate(2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate
6
1
(2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate(2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate
7
3
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303