8FCB: Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK1016790A

PDB ID: 8FCBDownload
MMDB ID: 232797
PDB Deposition Date: 2022/12/1
Updated in MMDB: 2023/07
Experimental Method:
electron microscopy
Resolution: 3.52  Å
Source Organism:
Similar Structures:
Biological Unit for 8FCB: octameric; determined by author
Molecular Components in 8FCB
Label Count Molecule
Proteins (8 molecules)
4
Transient Receptor Potential Cation Channel Subfamily V Member 4
(Gene symbol: TRPV4)
Molecule annotation
4
Transforming Protein Rhoa
(Gene symbol: RHOA)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
4
N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamideN-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide
2
4
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
3
4
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303