8F7P: BRAF kinase in complex with LXH254 (naporafenib)

PDB ID: 8F7PDownload
MMDB ID: 228994
PDB Deposition Date: 2022/11/20
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 2.74  Å
Source Organism:
Similar Structures:
Biological Unit for 8F7P: dimeric; determined by author
Molecular Components in 8F7P
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase B-raf
(Gene symbol: BRAF)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
N-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideN-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303