8F7O: BRAF kinase in complex with TAK580 (tovorafenib)

PDB ID: 8F7ODownload
MMDB ID: 228993
PDB Deposition Date: 2022/11/20
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 3.54  Å
Source Organism:
Similar Structures:
Biological Unit for 8F7O: dimeric; determined by author
Molecular Components in 8F7O
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase B-raf
(Gene symbol: BRAF)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303