8F5Y: Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1

PDB ID: 8F5YDownload
MMDB ID: 242963
PDB Deposition Date: 2022/11/15
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
Similar Structures:
Biological Unit for 8F5Y: tetrameric; determined by author and by software (PISA)
Molecular Components in 8F5Y
Label Count Molecule
Proteins (4 molecules)
2
Nuclear Receptor Subfamily 1 Group I Member 2
(Gene symbol: NR1I2)
Molecule annotation
2
Nuclear Receptor Coactivator 1
(Gene symbol: NCOA1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
(6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium(6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303