8F4S: Crystal Structure of the SARS-CoV-2 2'-O-Methyltransferase with Compound 5a bound to the Cryptic Pocket of nsp16

PDB ID: 8F4SDownload
MMDB ID: 236788
PDB Deposition Date: 2022/11/11
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
Similar Structures:
Biological Unit for 8F4S: dimeric; determined by author and by software (PISA)
Molecular Components in 8F4S
Label Count Molecule
Proteins (2 molecules)
1
2'-o-methyltransferase
Molecule annotation
1
Non-structural Protein 10
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
SODIUM IONSODIUM ION
2
1
4-[(E)-2-(2,4-dichlorophenyl)ethenyl]-6-(trifluoromethyl)pyrimidin-2-ol4-[(E)-2-(2,4-dichlorophenyl)ethenyl]-6-(trifluoromethyl)pyrimidin-2-ol
3
5
FORMIC ACIDFORMIC ACID
4
2
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303