8EXJ: Crystal structure of PTP1B D181A/Q262A phosphatase domain in complex with a JAK1 activation loop phosphopeptide

PDB ID: 8EXJDownload
MMDB ID: 232445
PDB Deposition Date: 2022/10/25
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.301  Å
Source Organism:
Similar Structures:
Biological Unit for 8EXJ: dimeric; determined by author and by software (PISA)
Molecular Components in 8EXJ
Label Count Molecule
Proteins (2 molecules)
1
Tyrosine-protein Phosphatase Non-receptor Type 1
(Gene symbol: PTPN1)
Molecule annotation
1
Tyrosine-protein Kinase Jak1 Activation Loop Peptide
(Gene symbol: JAK1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
PHOSPHATE IONPHOSPHATE ION
2
2
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303