8EL1: Structure of MBP-Mcl-1 in complex with ABBV-467

PDB ID: 8EL1Download
MMDB ID: 237105
PDB Deposition Date: 2022/9/22
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.406  Å
Source Organism:
Similar Structures:
Biological Unit for 8EL1: monomeric; determined by author
Molecular Components in 8EL1
Label Count Molecule
Protein (1 molecule)
1
Maltose/maltodextrin-binding Periplasmic Protein,induced Myeloid Leukemia Cell Differentiation Protein Mcl-1
(Gene symbol: MCL1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
alpha-D-glucopyranosealpha-D-glucopyranose
2
1
(7R,16R)-19,23-dichloro-10-{[2-(4-{[(2R)-1,4-dioxan-2-yl]methoxy}phenyl)pyrimidin-4-yl]methoxy}-1-(4-fluorophenyl)-20,22-dimethyl-16-[(4-methylpiperazin-1-yl)methyl]-7,8,15,16-tetrahydro-18,21-etheno-13,9-(metheno)-6,14,17-trioxa-2-thia-3,5-diazacyclononadeca[1,2,3-cd]indene-7-carboxylic acid(7R,16R)-19,23-dichloro-10-{[2-(4-{[(2R)-1,4-dioxan-2-yl]methoxy}phenyl)pyrimidin-4-yl]methoxy}-1-(4-fluorophenyl)-20,22-dimethyl-16-[(4-methylpiperazin-1-yl)methyl]-7,8,15,16-tetrahydro-18,21-etheno-13,9-(metheno)-6,14,17-trioxa-2-thia-3,5-diazacyclononadeca[1,2,3-cd]indene-7-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303